Trials Using Cohorts and Routine Health Data International symposium on their Efficiency and Analysis @clarerelton1 ‏@MRC_BSU #TwiCs

Trials Using Cohorts and Routine Health Data International symposium on their Efficiency and Analysis

Wednesday, 15th May, 2019

10am – 4.30pm

Wellcome Collection, Euston Road, London,

UK Innovative designs for randomized controlled trials (RCTs) utilising existing health data are increasingly used in healthcare intervention research. This includes trial designs that use existing data sources (randomized registry trials, administrative health record trials, and electronic health record trials) as well as Trials within Cohorts (TwiCs) designs.

How efficient are these trial designs?

How should these designs be analysed?

This one-day international symposium brings together experts in these designs in order to: share knowledge of the design, provide a forum to discuss and debate, and identify future directions for research.

For more details, contact

Call for abstracts

We welcome submissions for oral and poster presentations concerning any aspect relating to the efficiency and/or analysis of trials utilising cohorts or routinely collected health data. Submit your abstract to by 10th February 2019. Notification of acceptance will be by 10th March, 2019.

Preparing your abstract

1. Presenting author’s and co-authors’ name, affiliations and email address

2. Abstract title – clearly indicating the nature of the work presented in the abstract

3. Abstract text – 300 words max including: Background/aims, Methods, Results, and Conclusions

4. Up to 5 key words. Authors of accepted abstracts will be invited to publish in a special supplement of the journal Trials.


The symposium will be chaired by Dr Adrian Mander (Director, MRC Biostatistics Unit Hub for Trials Methodology Research, Cambridge University). Organising committee/ contributors: Clare Relton (Senior Lecturer, Pragmatic Clinical Trials Unit, Queen Mary University London, UK), Brett Thombs (Professor, Faculty of Medicine, McGill University, Canada) and leader of the ongoing Development of CONSORT reporting guidelines for RCTs using Cohorts and Routinely Collected Data with Linda Kwakkenbos (Assistant Professor, Radboud University, Netherlands), Ole Fröbert (adjunct Professor, School of Medical Sciences, Örebro University, Sweden), Ed Juszczak (Associate Professor, Director, Clinical Trials Unit, National Perinatal Epidemiology Unit, University of Oxford, UK), Isabelle Boutron (Professor, Paris Descartes University), Helena Verkooijen (Professor of Clinical Epidemiology, Department of Epidemiology, Julius Center Research Program Cancer, Utrecht Medical Center, Netherlands), Merrick Zwarenstein (Professor, Dept of Family Medicine, Epidemiology & Biostatistics, University of Western Ontario, Canada).

Seminar ~ @LeedsMedHealth SHED session focused on ‘Promoting a relevant evidence-base for care homes: spotlight on care home research’. @_DrReenaDevi ‏@GailMountain @piphedley

SHED talk – Promoting a relevant evidence-base for care homes: spotlight on care home research

School of Healthcare Education and Debate (SHED) session focused on ‘Promoting a relevant evidence-base for care homes: spotlight on care home research’. Join us on Tuesday 12th February, 15:00 – 17:00, seminar room 9.58b in the Worsley building to hear about the latest care home and research collaborations making a difference to quality of care and quality of life for older people.

Enhancing, maintaining and promoting quality in long-term care is a key focus for everyone who lives in, works in, provides or commissions care homes. As society’s need for care grows, an industry promising simple “un-evidence based” solutions to the complex challenges involved will proliferate. Scientists, care home providers and commissioners need to work together to ensure that only the most rigorous and relevant knowledge informs care home development and improvement.

You will hear from those delivering recent and ongoing high quality research and research partnerships. We will discuss the challenges and solutions associated with maintaining health and quality of life, improving the management of long-term conditions, and the organisation of long term care and services; all with ample time for discussion and networking.

This is an exciting opportunity to meet people with a different perspective, from different communities, but all concerned with enhancing and promoting quality in long-term care for older people. We look forward to welcoming you to the next SHED talk.

To register for this exciting session please use the following link –


How does @clahrcyh fit into the #NHSLongTermPlan #CLAHRCs #CLAHRC_Impact @OfficialNIHR #ARCs

. welcomes the Over the next 9 tweets we have highlighted where has already been working towards, and how our legacy will provide the basis to allow to demonstrate impact & success. 1/10

“The NHS will reduce pressure on emergency hospital services” p18 & our AAA theme’s unique data set that links 999 & 111 calls, to ED attendance, to admission or discharge is a powerful tool to model & explore new initiatives to address these challenges. 2/10 

“A strong start in life for children and young people” p45 is at the heart of our HCHF theme Innovative research approaches are allowing clinicians to deliver & evaluate services, placing evidence & effectiveness at the heart of all we do for young people. 3/10

“Universal smoking cessation service” p35 & our MHC theme have been at the forefront of both the research “Smoking Cessation Intervention for Severe Mental Ill Health” Trial & the implementation of smoking cessation in Mental Health settings. 4/10

“Digitally-enabled care will go mainstream across the NHS” p91 At the cutting edge of this work, our TACT theme’s recent publications on how to develop and how to assess Apps to support children living with ADHD are an excellent case study of how to ‘do’ apps. 5/10

“Supporting people to age well”p17. and our Frailty Theme Electronic Frailty Index has been a jewel in our crown & it is fantastic that it’s referenced by name. Demonstrating influencing the next 10 years of heath service provision. 6/10

“More NHS action on prevention and health inequalities” and a focus on upstream prevention p33. Our PHI theme has focused on practical tools to support frontline staff address those vital first conversations through Making Every Contact Count . 7/10

“Air Pollution” p38. Our HEOM theme has done ground-breaking work with YH ‘s to help identify the cost as a key public health risk factor. HEOM have developed a toolkit to help provide an evidence base to analyse possible policies that improve air quality. 8/10

“proven and affordable innovations get to patients faster” p77. Our TK2A theme uses implementation science & coproduction techniques to recognise & address the challenges of research into pratice. implementing NICE Obesity guidelines into physio. 9/10

“Improving patient safety will reduce patient harm” p107. Our EBT theme & will support the goal of understanding & implementing advances in . The theme’s ABC training has reached over 300 staff across YH. 10/10 


Seminar ~ #PPI development of risk score package to predict the risk of death or sepsis @yqsrdotorg @JudithDyson1 @RuthMBaxter @DrGillianJanes @Improve_Academy

The Yorkshire Quality and Safety Research group are delighted to invite you to our upcoming research seminar:

Practitioner and patient involvement in the development of an automated risk score package to predict the risk of death or sepsis following emergency medical admission to hospital.

 Dr Judith Dyson, Senior Lecturer Implementation Science, University of Hull

Dr Claire Marsh, Patient and Public Engagement Lead, Yorkshire & Humber Improvement Academy

 When/where: Thursday 24th January 2019, 12.30-1.30pm in the Sovereign Lecture Theatre at the Bradford Royal Infirmary.

 Abstract: Quality and safety of care remains a priority for the NHS but approximately 5% of deaths in English hospitals are preventable, and attributed to poor quality of care.  Patients who are admitted to hospital towards the end of their lives can experience inadequate decision making, poor communication and suboptimal treatment and there is the need for clinical staff to recognise as soon as possible that a person is dying and to communicate this clearly to others.  Over a two year research study in two NHS hospitals, a suite of four automated risk scores was developed that use routinely collected electronically stored data to provide clinicians with estimates of patients’ risk of death and sepsis during their stay in hospital. These scores rely on two key clinical data sources – the patients vital signs data as defined and monitored by the National Early Warning Score (NEWS) and routine blood test results.  Staff and patient involvement has been integral to the development of the scores.  In this presentation, we outline the findings of 8 focus groups involving 11 service users and carers, and 45 health care practitioners, and explain how these have contributed to an understanding of value and potential use of the scores in practice.

To book a place, register at:

Seminars will be followed by food, drinks, and an opportunity for further discussion.  

Tick Tock……have you submitted your @HSRN_UK abstract deadline 13/01

The HSRUK19 conference is open to everyone interested in health services and systems research, and offers you the opportunity to hear about the latest research, build your network and meet the agenda-setters.


Deadline 13 January! The 2019 call invites submissions for individual abstracts (for oral presentation and/or poster presentation) or for whole sessions (comprising a number of linked oral presentations within one session). We welcome abstracts on all aspects of health services, systems and policy research, especially research that will have a positive impact on patients and the health service, builds research capacity in the NHS or advances research methodology.

Upload your proposal now:


Registration is now open! Book your place today and benefit from early bird fees, until 31 March. HSRUK members get significant discounts on registration. If you’re not an organisational member, join HSRUK today, and you and your colleagues will save £100 per person on registration fees. Get in touch if you’d like to roll this into your conference registration payment.


We have some great plenaries confirmed, including:

  • The impact of health research: future priorities and strategies
  • Social care research, policy and practice
  • Using patient experience data for service improvement
  • Researching the healthcare workforce: what do we need to know?

We hope you’ll join us at HSRUK19 for two days of cutting-edge research in an exciting programme of presentations, posters, themed sessions and workshops.

Best wishes,
The HSRUK team

Workshop ~ Long Term Neurological Conditions – Building Collaborations and Developing Research Capacity @Devices4Dignity @AHSN_YandH

Long Term Neurological Conditions – Building Collaborations and Developing Research Capacity

Fri 1 February 2019, 12:00 – 16:00 GMT.
Westfield Health, 60 Charter Row, Sheffield, S1 3FZ

NIHR Devices for Dignity Med Tech Cooperative (D4D) are working in partnership with the Yorkshire & Humber AHSN to host a workshop to identify potential technology solutions that address unmet needs for people living with long term neurological conditions

One of D4D’s research aims is to deliver health and quality of life benefits for many of the 10 million people in the UK living with Long Term Neurological Conditions, by supporting people to live well, and maximise their function, independence and ability to self-manage, through the collaborative development, and/or repurposing, of technology.

Attendance is invited from academics, health care professionals, engineers, patients, carers and anyone with an interest in or knowledge of long term neurological conditions.

The objectives for the workshop are:

  • Identify clinical and academic skills
  • Develop novel research ideas
  • Link our emerging ideas and research activities to funding calls
  • Map out research activities to exisiting funding streams
  • Plan next steps

Attendees will be encouraged to form multi-disciplinary collaborations and project teams during the workshop, with the aim for project ideas generated during the workshop to be taken forward after the event.

We’d like attendees to help define the areas of focus for this unmet needs workshop by providing information in the extended questions below when registering to attend. We’d like this information before Friday 25th January 2019. The more information you give us, the better we can meet your needs on the day. The day will then be driven through teamwork around potential unmet needs, with valuable outcomes around next steps, including opportunities for funding.

This is a great opportunity to work directly with D4D and our national network of partners in the development of technology based projects to assist the millions of people living with complex neurological conditions.

Places are limited and prior registration is essential. Lunch will be provided – please provide further details when you register if you have specific dietary requirements.

Should you have any queries, please contact