Research Design Service for the East Midlands Update December 2014

Research Design Service for the East Midlands   

R&D Email Update – December 2014 Latest news from online R&D sources


Government / Department of Health News

MHRA Triennial Review

The Department of Health reviews its arm’s length bodies once every 3 years.  This triennial review looks at what the Medicines and Healthcare Products Regulatory Agency (MHRA) does and how. There is an opportunity to attend one of three workshops in London or complete an online response form.


  • NHS Health Check programme: priorities for research

Public Health England (PHE)

This document is published as a draft for discussion.

The consultation closes on December 19th

Download the consultation response form

The NHS Health Check programme is a national risk assessment, awareness and management programme that systematically targets the top seven causes of preventable deaths: high blood pressure, smoking, high cholesterol, obesity, poor diet, physical inactivity and alcohol consumption. The early identification and management of these risks could substantially reduce the morbidity, mortality and health inequalities that result from the diseases they cause, including diabetes, chronic kidney disease, dementia and cardiovascular disease.

The purpose of the paper is for PHE to consult on the key research priorities for the NHS Health Check programme. Research priorities for consideration are categorised according to the three key elements of the programme – recruitment, assessment/intervention and outcomes

  • NHS Health Check programme: Literature Review

This literature review, produced by the PHE Knowledge and Library Service with the support of the NHS Health Check Expert Scientific and Clinical Advisory Panel, identifies evidence relevant to the NHS Health Check programme

 The NHS Five Year Forward View

The Five Year Forward View has been developed by partner organisations that deliver and oversee health and care services including NHS England, the Care Quality Commission, Monitor, Public Health England, Trust Development Authority and Health Education England. Patient groups, clinicians and independent experts have also provided their advice to create a collective view of how the health service needs to change over the next five years if it is to close the widening gaps in the health of the population, quality of care and the funding of services.

The Five Year Forward View confirms support for the research and innovation agenda and the work of NIHR.


National Institute for Health Research (NIHR)

Round 5 of the NIHR New Media Competition

The competition enables researchers, patients and members of the public who have been involved in recently completed clinical, applied health or social care research to communicate the message about why the research is important, what is being done and the impact it may have.

In this round there are two categories of competition and an additional special prize.

Category 1.  Raising awareness of your research

Category 2.  Recruitment to |NIHR clinical trials / encouraging participation in a research study

Special prize.  How patient and public involvement has added value to a research project

The competition closes at midnight on Tuesday 31st March 2015

CLAHRC Community e-Newsletter!patient-safety-newsletter/c8sc

The latest CLAHRC Community e-Newsletter focusses on patient safety and provides latest news and interesting developments from across the thirteen CLAHRCs.


NIHR Clinical Research Network (CRN)

 Launch of INSIGHT Magazine

The Central CRN Communications team has announced the launch of the new flagship magazine: Insight.  This replaces ‘News from the Networks’ and reflects the new structure of the CRN. The theme for the first edition is ‘progress’ which is introduced by Jonathan Sheffield, CRN Chief Executive Officer.

New aphasia resources for researchers conducting stroke studies

The NIHR Clinical Research Network: Stroke (CRN: Stroke) has launched a new resource pack designed to help researchers involve more patients with aphasia participate in clinical studies.

The free resource pack includes aphasia-friendly templates to assist researchers in developing study documents to address the needs of this group. These include:

  • Study information sheets and forms designed specifically for people with aphasia
  • Tips on how to encourage people with aphasia to participate in studies
  • A wide range of images which depict the research pathway to increase understanding


AMRC – Association of Medical Research Charitie

AMRC’s challenge for government 2015

AMRC calls on the current and future governments to support the UK medical research sector to ensure charities can continue to fund excellent science and develop life-saving treatments for patients.

The challenge builds on the three areas of need highlighted in the infographics sheets published by AMRC in September – strong foundations, skilled people and research at the heart of the NHS.

The new challenge builds on these three overarching themes by calling on current and future governments to:

  • Commit to stable investment for research – including an increase in the Charity Research Support Fund to reflect the increase in charity investment in research.
  • Support people and environment that enable research to flourish – encouraging training, development and retention of researchers, technicians and healthcare workers and a flexible, innovation-friendly regulatory environment.
  • Position research at the heart of the NHS – including close working with NHS England and CCGs to make sure Excess Treatment Costs are paid for and patient data can be shared safely and securely to support research and facilitate adoption of innovation.
  • An Essential Partnership: A guide for charities working with industry

This document provides in-depth advice and guidance for AMRC members wishing to collaborate with the pharmaceutical, biotechnology and other healthcare industries.


Health Research Authority

Current consultations

  • Protocol guidance and template for use in a Clinical Trial of an Investigational Medicinal Product (CTIMP) – for consultation in use

Further information and access to the guidance and template:

Feedback from users is requested by 31st May 2015

Recruiting participants

The Health Research Authority (HRA), has launched a public dialogue exercise to gain better understanding of public attitudes towards the recruitment of participants in health research. “Recruiting participants for health research: a public dialogue” is being undertaken by the HRA with support from Sciencewise.  Initially intended to take place over November 2015, the public dialogue has been extended to 5 January 2015.


Patient and Public Involvement

 James Lind Alliance

Newsletter December 2014

The latest edition of the JLA Affiliates Newsletter is available on the website:

This provides news and progress updates from a range of the research priority setting partnerships


 Funding Opportunities & News

  • NIHR RfPB – changes to funding limit

RfPB have introduced a new opportunity to fund “higher risk” research, with a rule of thumb upper limit of £150K. Higher risk refers to the likelihood of the research leading to patient benefit, not risk to the patient. Examples of studies that might fall within this category of ‘higher risk’ research include:

Observational studies using clinical databases, which might provide preliminary estimates of an effect size that would be useful in the design of a clinical trial

  • Observational studies to establish for example the practicality and acceptability of changes to clinical practice, or the best means to ensure and measure adherence, prior to a formal evaluation
  • Developing and refining interventions
  • Developing new scales or outcome measures
  • Exploratory studies, e.g. using qualitative methods, that might provide insights into an intractable problem
  • Additional follow up of patients in a completed clinical trial
  • Post-market surveillance for unknown side-effects of a drug (Phase IV trials)
  • A systematic review, especially where the number of relevant studies is likely to be limited

See RfPB Guidance for Applicants for further details:

NIHR EME Programme

  • Proposed research areas for EME commissioned calls

The following broad topics are likely to be commissioned during the next year and are anticipated to open on the date shown below. However, titles and timings may change.

  • Metabolic liver disease (including NAFLD) – February 2015
  • Pancreatitis – February 2015
  • Very low energy diets – February 2015
  • Diagnosis and treatment of allergies – February 2015
  • Early makers of treatment response – June 2015
  • Irritable bowel syndrome – June 2015


New Reports / Publications

NIHR EME Programme Publications

The first projects funded through the EME Programme researcher-led workstream are now publishing in the NIHR Journal Efficacy and Mechanism Evaluation. All EME studies will publish in this journal providing open access to the full results to a wide audience.


Conferences & Courses

HSRN Symposium 2015: Abstract call

The Health Services Research Network (HSRN) Symposium 2015 will take place on 1-2 July 2015 in Nottingham. The Symposium presents the leading edge of health services research in a multidisciplinary programme that includes research presentations and posters, alongside plenaries from research and service leaders. Abstracts, proposals to run sessions and nominations for the HSRN Impact award are now being invited. Closing date: 16 January 2015


Useful Websites:


We provide FREE advice on research design to researchers in the East Midlands who are developing proposals for open, national, peer-reviewed funding competitions for applied health or social care research.

Gill Sarre

The NIHR Research Design Service for the East Midlands

University of Nottingham,

Room 2106, C Floor South Block, Queen’s Medical Centre

Nottingham, NG7 2UH

Tel: 0115 9249924 ext 70709


17th December 2014

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